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Antibiotic resistance profiles in Enterobacteriaceae isolated fromsalted cattle hides and sheep skin samples were examined in thisstudy. Antibiotic resistance profiles of 27 cattle hide and 28sheep skin isolates, obtained from five salted cattle hide and fiveskin samples originating in different countries such as Dubai,Turkey, Israel, Australia, Lebanon, U.S.A. and South Africa,were examined by disc diffussion susceptibility method using 24different antimicrobial agents. Seventy percent of the salted hideisolates and sixty-eight percent of the salted sheep skin isolatesexhibited resistance to three or more of 24 antimicrobial agentsused. Less than 50% of the isolates was resistant to tobramycin(13%), cephalothin (16%), tetracycline (16%), amoxycillinclavulanate(25%), ampicillin-sulbactam (29%), piperacillintazobactam(38%), cefoxitin (20%), ceftriaxone (45%),ceftazidime (33%), cefuroxime sodium (45%), trimethoprimsulfamethoxazole(25%), ampicillin (45%), chloramphenicol(35%) and nalidixic acid (42%). Although 71% of isolates exhibitedresistance to aztreonam, all isolates were susceptible tonorfloxacin. Resistance to amikacin (5%), streptomycin (9%),kanamycin (9%), gentamicin (5%), imipenem (4%), meropenem(2%), ciprofloxacin (5%) and ofloxacin (2%) was not very commonamong the isolates. Our research results showed that multidrugresistantEnterobacteriaceae were common on both salted cattlehide and sheep skin samples. Therefore, we suggest effectiveantibacterial applications during salt curing of hides and skins toeradicate these multidrug-resistant bacteria in the leather industry.