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The diabetic patients may sometime suffer from foot lesions, foot ulcers and amputation that adversely affect their quality of life. In this respect, good footwear has a critical significance for diabetic foot patients. The aim of this study to evaluate the potential efficacy of mimosa, quebracho, and essential oils of Origanum onites, Origanum onites oleum, and Origanum minutiflorum, against Acinetobacter pittii, Bacillus cereus, and Klebsiella pneumoniae, which was isolated from diabetic foot patient. According to our results, the mimosa extracts were slightly more efficient when compared to quebracho extracts to control the bacterial growth of A. pittii (8.77±0.58-35.12±8.41% inhibition for three doses), and K. pneumoniae (21.40±0.48-47.04±0.51% inhibition) except B. cereus (71.1±0.31-23.51±1.66% inhibition). But these inhibition percentages remained at lower levels. On the other hand, essential oil samples of O. onites, O. onites oleum, and O. minutiflorum at tested doses have considerably high antibacterial effects against A. pittii, B. cereus, and K. pneumoniae. The tested essential oils almost completely inhibited B. cereus with percentages of inhibition ranging from 96.18±2.98-100±0.00. Also, the bacterial growth of K. pneumoniae and A. pittii was inhibited by 88.01±2.36 to 100±0.00% and 71.42±12.57 to 100±0.00%, respectively. Moreover, the essential oils of O. onites, O. onites oleum, and O. minutiflorum, had bactericidal activity against A. pittii, and K. pneumoniae but bacteriostatic activity against B. cereus. This potency for essential oil of Origanum species may be evaluated for diabetic footwear. More detailed technical studies are required for the application of Origanum species to leather footwear.