Profiles of regulatory protein in muscle tissue

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Hannah Kim Taejeong Song


By Hannah Kim, Medical Sciences

Advisor: Taejeong Song

Presentation ID: AM_B22

Abstract: Striated muscles coordinately contract and relax for generating mechanical force. Cardiac muscle in the heart pumps blood that circulates the body, and skeletal muscle moves bones voluntarily for functions such as mobility and posture maintenance. In striated muscles, there are two types of muscle fibers, slow-twitch and fast-twitch, depending on the expressions of myosin heavy chain (MHC). Slow twitch fiber is involved in prolonged physical exertion, while fast twitch fiber is involved in short bursts of movement. The force generation and speed of muscle contraction are also highly regulated by a class of sarcomere proteins called Myosin Binding Protein-C (MyBP-C). The three types are slow skeletal MyBP-C (ssMyBP-C), fast skeletal MyBP-C (fsMyBP-C), and cardiac MyBP-C (cMyBP-C). cMyBP-C has been heavily studied due to its implications in cardiomyopathies. Phosphorylation of cMyBP-C is critical for regulating muscle function and development of cardiac myopathy. However, recent studies reported multiple phosphorylation sites of ssMyBP-C. Thus, this study aims to examine total and phosphorylation of ssMyBP-C in slow and fast twitch muscles, soleus and extensor digitorum longus.

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AM Poster Session -- Great Hall -- B: Health & Body